Quick Facts
- Sample: Blood
- Fasting: No fasting is required. Stop biotin consumption at least 72 hours prior to the collection.
- Turnaround: 1-3 days. May take longer based on weather, holiday or lab delays.
What This Test Measures
This test measures Thyroid Peroxidase (TPO) antibodies in your blood. TPO antibodies are immune proteins that your body produces when it mistakenly targets the thyroid peroxidase enzyme, an enzyme that plays a key role in thyroid hormone production. This test does not measure thyroid hormones such as TSH, T3, or T4.
Because this is an antibody test, it does not directly measure thyroid function or hormone output. Instead, it identifies immune activity that may be associated with autoimmune thyroid conditions. Elevated TPO antibodies are commonly seen in people with chronic thyroiditis, though some people without thyroid disease also have detectable levels.
Benefits
- Detects TPO antibodies linked to autoimmune thyroid activity.
- Supports evaluation when other thyroid test results are inconsistent.
- Provides insight for pregnant women with autoimmune disorders.
- Convenient blood test with no fasting required.
- Helps healthcare providers assess autoimmune thyroid involvement.
Who Is This Test For?
- Individuals with symptoms that may suggest Hashimoto thyroiditis.
- Individuals with symptoms that may suggest Graves' disease.
- People whose prior thyroid test results were inconsistent.
- Pregnant women with autoimmune disorders wanting to assess baby's thyroid risk.
- Women, since antibody prevalence increases with age.
- Individuals working with a healthcare provider on thyroid-related concerns.
How It Works
- Order Your Test Online
- Visit a Local Lab
- Get Results Online
FAQ
1. What is the purpose of this thyroid test?
This test detects and measures Thyroid Peroxidase (TPO) antibodies in your blood. It helps a healthcare provider evaluate whether autoimmune activity may be affecting your thyroid, particularly in connection with Hashimoto thyroiditis or Graves' disease. This is an antibody test, not a direct measurement of thyroid hormone levels, and it does not diagnose a condition on its own.
2. Who would benefit from this test?
This test may be considered by individuals experiencing symptoms associated with Hashimoto or Graves' disease, or by those whose other thyroid test results have been inconsistent. Pregnant women with autoimmune disorders may also consider this test to help assess their baby's risk of thyroid dysfunction. A healthcare provider can help determine if this test is appropriate for your situation.
3. When should I order this test?
You may consider ordering this test if you are experiencing symptoms that your healthcare provider believes could be related to Hashimoto or Graves' disease. It may also be useful when prior thyroid testing has produced results that need further context. This test does not replace a full medical evaluation.
4. How does this test differ from other thyroid tests?
This test measures TPO antibodies, which are immune markers, rather than thyroid hormones like TSH, T3, or T4. Unlike hormone tests that reflect thyroid output directly, this antibody test reflects immune system activity that may be targeting the thyroid gland. It is not interchangeable with hormone or binding protein testing.
5. Do I need to fast before this test?
No fasting is required for this test. You should stop biotin consumption at least 72 hours prior to your blood collection.
6. How quickly will I get results?
Results are typically available in 1-3 days. Results may take longer based on weather, holidays, or other lab delays.
7. How do I interpret the results?
The meaning of your TPO antibody result depends on your symptoms, medical history, and other laboratory findings. TPO antibody levels are often considered alongside other thyroid measurements when a healthcare provider evaluates your overall thyroid health. An elevated result does not automatically confirm a thyroid condition, and a normal result does not rule one out. This antibody result should not be interpreted as a thyroid hormone level.
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
8. What should I do if my results are abnormal?
If your results fall outside the expected range, review them with a qualified healthcare provider. They can help determine whether additional evaluation or testing may be appropriate based on your individual health history. Do not stop prescribed medication unless instructed by your healthcare provider.
9. How often should I get tested?
Testing frequency should be determined as directed by your healthcare provider based on your individual symptoms and health history. There is no standard repeat testing schedule associated with this test.
Pre test preparation
No fasting is required. Stop biotin consumption at least 72 hours prior to the collection. Do not stop prescribed medication unless instructed by your healthcare provider.
