Tissue Transglutaminase (tTG) Blood Test, IgG
A tTG Blood Test is useful in diagnosing gluten-sensitive enteropathies, such as Celiac Sprue Disease, and an associated skin condition, dermatitis herpetiformis in patients who are IgA-deficient.
Recommended single screening test for IgA-deficient individuals with suspected celiac disease. (IgA testing recommended to identify IgA deficiency.)
For individuals with IgA deficiency:
-Evaluating patients suspected of having celiac disease, including patients with compatible clinical symptoms, patients with atypical symptoms, and individuals at increased risk (family history, previous diagnosis with associated disorder, positivity for HLA DQ2 and/or DQ8
-Screening test for dermatitis herpetiformis, in conjunction with endomysial antibody test
-Monitoring adherence to gluten-free diet in patients with dermatitis herpetiformis and celiac disease
Testing for tissue transglutaminase (tTG) IgA antibodies is preferred over tTG IgG antibodies, except in the presence of IgA deficiency. This test should not be solely relied upon to establish a diagnosis of celiac disease. It should be used to identify patients who have an increased probability of having celiac disease and in whom a small intestinal biopsy is recommended.
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