Celiac Disease Profile II Blood Test

The Celiac Disease Profile II Blood Test measures the IgA antibody levels to help diagnose celiac disease and monitor response to a gluten-free diet.

Quest
LabCorp

Sample Report

Test Code: 165134

CPT Code: 82784,86364(x2),86231

Also Known As:

Methodology:

Enzyme Immunoassay (EIA) • Indirect Immunofluorescence

Preparation:

No special preparation is required.

Test Results:

3-4 days. May take longer based on weather, holiday or lab delays.

Description

The Celiac Disease Profile II Blood Test includes:

Endomysial Antibodies, IgA
Tissue transglutaminase Antibodies, IgA
Tissue transglutaminase Antibodies, IgG
Total IgA

What is the purpose of this test?

Order Celiac Disease Profile II Blood Test to measure the IgE antibody levels to help diagnose celiac disease and monitor response to a gluten-free diet. Celiac Disease (CD) is a hereditary autoimmune disease that attacks the digestive system after eating gluten-free foods. Gluten is a protein in cereal grains like rye, barley, and wheat.

The immune system usually combats viruses and bacteria from spreading throughout the body. However, upon consuming gluten, the immune system of individuals with celiac disease mistakenly attacks the walls of the small intestine as if it contained a virus. As a result, it causes damage to the digestive tract and prevents the body from absorbing the nutrients it needs.

This Celiac Disease Profile II Blood Test screens for the following antibodies:

Endomysial Antibodies (EMA), IgA - antibodies produced in response to chronic damage to the small intestinal walls. EMA IgA antibodies have been detected in about 100% of individuals with celiac disease and 70% of those with dermatitis herpetiformis (a gluten-sensitive condition that triggers itchy, burning, blistering rashes).
Tissue transglutaminase Antibody (tTG), IgA - is the most commonly ordered test to screen for celiac disease. This test is recommended by the American College of Gastroenterology and the American Gastroenterology Association as the most diagnostically accurate blood test for detecting celiac disease. It can also monitor the condition and help evaluate treatment effectiveness.
Tissue transglutaminase Antibody (tTG), IgG - is a different antibody targeting the small intestine. The tTG IgG test is often used only for celiac disease screening in patients with low total IgA.
Immunoglobulin A (Total IgA) - this test is typically ordered in addition to the tTG IgA test to help detect an IgA deficiency, which occurs in approximately 2-3% of individuals with celiac disease. If you have an IgA deficiency, the test for tTG IgA may be negative even if you have celiac disease (false-negative test results).