Triiodothyronine (T3) Free Blood Test, Dialysis and LC/MS-MS (Endocrine Sciences)

A T3 free blood test, dialysis and LC/MS-MS is used to evaluate thyroid function and assess abnormal binding protein disorders.

Description

Evaluate thyroid function and assess abnormal binding protein disorders

Direct measurement of FT₃ by equilibrium dialysis, high-pressure liquid chromatography, and tandem mass spectrometry (ED-HPLC/MS-MS) provides enhanced accuracy over commonly used analog (automated) methods and is not affected by clinical conditions that impact protein binding capacity.^1-4 Examples of clinical conditions in which the FT₃ by dialysis and MS/MS method may be preferred include congenital absence of thyroxine-binding protein (TBG);¹ pregnancy;^1-5 administration of oral contraceptives or hormone therapy;⁶ administration of atypical antipsychotic medications;⁷ malignancy or other critical illnesses