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Corticosteroid-Binding Globulin (CBG) Blood Test

The CBG Blood Test measures Corticosteroid-binding globulin (CBG, transcortin), the main transport protein for cortisol and corticosterone in vertebrates. This protein binds glucocorticoids with high affinity. In some species, it also binds progesterone and to a lesser extent testosterone. Its specificity varies among species. CBG is important in regulating the actions of glucocorticoids.

Sample Report

Test Code: 500130

Also Known As: CBG; Corticosteroid-binding Globulin (CBG) Transcortin

Methodology: Radioimmunoassay (RIA)

Preparation: No special preparation required.

Test Results: 7-10 days. May take longer based on weather, holiday or lab delays.

Description

Corticosteroid-binding globulin (CBG) is the specific high-affinity plasma transport glycoprotein for cortisol. Stress-induced falls in CBG levels may heighten hypothalamic–pituitary–adrenal axis responses and CBG:tissue interactions may allow targeted cortisol delivery. Three genetic variants of CBG have been identified that reduce cortisol binding affinity and/or CBG levels.

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