Quick Facts
- Sample: Blood
- Fasting: No special preparation is required
- Turnaround: 5-10 days (may take longer based on weather, holiday, or lab delays)
What This Test Measures
This test measures dehydroepiandrosterone sulfate (DHEA-S) in the blood using liquid chromatography-tandem mass spectrometry (LC/MS-MS), a highly sensitive and specific laboratory method. DHEA-S is a hormone produced by the adrenal glands and serves as a precursor to sex hormones, meaning your body uses it to help produce other hormones downstream.
The result reflects your circulating DHEA-S level as directly measured by LC/MS-MS. This test reports a single analyte, DHEA Sulfate, and does not separately report free and total forms. Because DHEA-S is a precursor hormone, this result reflects adrenal output of DHEA-S itself rather than the levels of the sex hormones it may contribute to downstream.
Benefits
- Measures DHEA-S using sensitive, specific LC/MS-MS methodology
- Helps evaluate adrenal gland function
- Supports assessment of hormonal imbalance symptoms
- Provides a lab value to discuss with your healthcare provider
- Uses a simple blood draw with no special preparation
Who Is This Test For?
- Individuals experiencing symptoms of adrenal insufficiency
- Individuals experiencing symptoms of andropause or menopause
- Individuals with unexplained infertility
- Individuals with suspected polycystic ovarian syndrome (PCOS)
- Individuals with suspected congenital adrenal hyperplasia (CAH)
- Individuals with suspected adrenal tumors, Cushing's syndrome, or Addison's disease
How It Works
- Order Your Test Online
- Visit a Local Lab
- Get Results Online
FAQ
1. What is the purpose of this hormone test?
This test measures dehydroepiandrosterone sulfate (DHEA-S), a hormone produced by the adrenal glands that serves as a precursor to sex hormones, using LC/MS-MS methodology. The result can help a healthcare provider evaluate adrenal gland function and investigate possible hormonal imbalances. This is a single-analyte test, not a panel, and it does not diagnose any condition on its own.
2. Who should consider this test?
This test may be considered by individuals with symptoms of adrenal insufficiency, andropause, or menopause, as well as those with unexplained infertility, suspected polycystic ovarian syndrome (PCOS), congenital adrenal hyperplasia (CAH), adrenal tumors, Cushing's syndrome, or Addison's disease. You might also consider this test if you're experiencing symptoms such as irregular periods, decreased libido, fatigue, depression or anxiety, osteoporosis, muscle weakness, abnormal hair growth or loss, or acne. A healthcare provider can help determine whether this test fits your symptoms and overall situation.
3. How does this test differ from other hormone tests?
Unlike tests that measure the sex hormones DHEA-S may help produce, or other adrenal or pituitary hormones, this test specifically targets DHEA-S itself. It reports a single, directly measured analyte rather than a calculated value, and it does not include separate free versus total measurements. Because DHEA-S is a precursor hormone, the result reflects adrenal precursor output rather than downstream hormone activity.
4. Do I need to fast before this test?
No special preparation is required for this test.
5. How quickly will I get results?
Results are typically available in 5 to 10 days, though this may take longer based on weather, holidays, or lab delays.
6. How do I interpret my results?
Interpreting your DHEA-S result depends on your individual symptoms, medical history, sex, age, and any related lab results your provider may consider. Because DHEA-S is a precursor hormone, results are often reviewed alongside other clinical information rather than in isolation. An abnormal result doesn't automatically confirm a hormonal condition, and a normal result doesn't rule one out.
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
7. What should I do if my results are abnormal?
Review your results with a qualified healthcare provider, who can help determine what they mean in the context of your health history and whether further evaluation is appropriate. Do not stop prescribed medication unless instructed by your healthcare provider.
8. How often should I get tested?
Testing frequency should be determined by your healthcare provider based on your individual health needs and the reason for testing. There is no universal retesting schedule for this test, so follow your provider's guidance.
Pre test preparation
No special preparation is required.
