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Dehydroepiandrosterone Sulfate (DHEA-S), LC/MS-MS (Endocrine Sciences)

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The DHEA-S, LC/MS-MS (Endocrine Sciences) Blood Test is used to measure DHEA-S levels in the blood to determine the functioning of the adrenal gland and to diagnose hormonal imbalances.


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Test Code:


CPT Code(s):


Also Known As:



Liquid Chromatography/Tandem Mass Spectrometry (LC/MS-MS)




No special preparation is required.

Test Results:

2-3 days. May take longer based on weather, holiday, or lab delays.

Walk-In Lab is prohibited from selling LabCorp tests to residents in the following states:NY, NJ, RI, MA, MD

What is the purpose of this test?

A DHEA-S, LC/MS-MS blood test is a laboratory test used to measure the level of dehydroepiandrosterone sulfate (DHEA-S) in the blood. DHEA-S is a hormone produced by the adrenal glands, and it is a precursor to both male and female sex hormones. This test is often used to evaluate adrenal gland function and to help diagnose conditions related to hormonal imbalances, such as adrenal tumors, polycystic ovary syndrome (PCOS), and congenital adrenal hyperplasia (CAH). The DHEA-S, LC/MS-MS test is a highly sensitive and specific test that uses liquid chromatography-tandem mass spectrometry (LC/MS-MS) technology to measure the DHEA-S level in the blood. This method provides accurate and reliable results, even at very low levels of DHEA-S.

The DHEA-S, LC/MS-MS blood test can be used to monitor treatment for hormonal imbalances and to assess fertility and menopause status. In women, low levels of DHEA-S may be associated with decreased fertility, while high levels of DHEA-S may be associated with PCOS. In men, low levels of DHEA-S may be associated with decreased libido and erectile dysfunction. Overall, the DHEA-S, LC/MS-MS blood test is an important tool for diagnosing and monitoring conditions related to hormonal imbalances. It is a safe and non-invasive test that provides valuable information for healthcare providers to make informed decisions about the management of their patients' health.


Who would benefit from this test?

The (DHEA-S), LC/MS-MS (Endocrine Sciences) Blood Test would be beneficial for:

  • Individuals experiencing symptoms of adrenal insufficiency
  • Individuals experiencing symptoms of andropause or menopause
  • Individuals with unexplained infertility
  • Individuals with suspected polycystic ovarian syndrome (PCOS)
  • Individuals with suspected congenital adrenal hyperplasia (CAH)
  • Individuals with suspected adrenal tumors
  • Individuals with suspected Cushing's syndrome
  • Individuals with suspected Addison's disease
  • Individuals with suspected hirsutism or virilization


When should I order a (DHEA-S), LC/MS-MS (Endocrine Sciences) Blood Test?

Several symptoms may indicate the need for a (DHEA-S), LC/MS-MS (Endocrine Sciences) blood test. These include:

  • Irregular periods
  • Decreased libido
  • Fatigue
  • Depression or anxiety
  • Infertility
  • Osteoporosis or bone loss
  • Muscle weakness
  • Abnormal hair growth or loss
  • Acne

If you're experiencing any of these symptoms, talk to your healthcare provider about getting a DHEA-S blood test. They can help determine if the test is necessary and what steps to take next.

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