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Inflammatory Bowel Disease (IBD) Profile Blood Test

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The IBD blood test is used to rule out Crohn's disease and ulcerative colitis.


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Test Code:


CPT Code(s):


Also Known As:

Bowel Disease; Chrohn's Disease; IBD; Ulcerative Colitis


Atypical ANCA: indirect fluorescent antibody (IFA); Saccharomyces cerevisiae, IgA, and IgG: enzyme immunoassay (EIA)




No special preparation required.

Test Results:

2-3 days. May take longer based on weather, holiday or lab delays.

Walk-In Lab is prohibited from selling LabCorp tests to residents in the following states:NY, NJ, RI, MA, MD

Inflammatory bowel disease (IBD) is a chronic disorder that affects about a million people in the United States. Periods of active disease may alternate with periods of remission. During a flare-up, a patient may experience frequent bouts of watery and/or bloody diarrhea, abdominal pain, weight loss, and fever. Between these flare-ups, symptoms frequently diminish. The cause of IBD is unknown, but these diseases are thought to be due to an autoimmune process that has been triggered by a genetic predisposition, a viral illness, and/or an environmental factor.


IBD Profile includes:


  • Atypical perinuclear antineutrophil cytoplasmic antibodies (pANCA); Saccharomyces cerevisiae, IgA; Saccharomyces cerevisiae, IgG

IgA and IgG antibody testing for S cerevisiae is useful adjunct testing for differentiating Crohn's disease and ulcerative colitis. Nearly 80% of Crohn's disease patients are positive for either IgA or IgG. In ulcerative colitis, <15% are positive for IgG, and <2% are positive for IgA. Fewer than 5% of healthy controls are positive for either IgG or IgA antibodies, and no healthy controls had antibodies for both. The atypical ANCA pattern has been observed in a significant percentage of patients with ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis.

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