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Parathyroid Hormone-related Peptide (PTH-rP) (Endocrine Sciences) Plasma Test

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The Parathyroid Hormone-Related Peptide (PTH-RP) Plasma Test measures the PTH-RP hormone levels in the blood to help diagnose hypercalcemia.


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Test Code:


CPT Code(s):



Electrochemiluminescence (ECL)




No special preparation is required.

Test Results:

6-8 days. May take longer based on weather, holiday or lab delays.

Walk-In Lab is prohibited from selling LabCorp tests to residents in the following states:NY, NJ, RI, MA, MD

What is the purpose of this test? 

Order this Parathyroid Hormone-Related Peptide (PTH-RP) Plasma Test to measure the PTH-RP hormone levels in the blood to help diagnose hypercalcemia. The PTH, a hormone produced by the parathyroid glands, regulates calcium, phosphorus, and vitamin D levels in the blood and bones. This PTH-RP Plasma Test is usually ordered to determine the cause of abnormally high calcium levels (hypercalcemia). 


Abnormal levels of PTH cause irregulated calcium levels that may lead to severe health conditions, such as:

  • Hypercalcemia
  • Osteopenia
  • Osteoporosis
  • Kidney stones
  • Kidney failure
  • Heart disease


Therefore, this test may also be ordered to monitor the condition of individuals with kidney disease and hyperparathyroidism (too much PTH in the blood).


What conditions cause elevated PTH-RP levels?

Several conditions may cause elevated PTH-RP levels, but the most common cause is various cancers. Approximately two-thirds of individuals with cancer have an elevated calcium level. This condition is called humoral hypercalcemia of malignancy (HHM) or paraneoplastic hypercalcemia.


When should I order a PTH-RP Plasma Test?

Individuals may order this PTH-RP Plasma Test if they have experienced the symptoms associated with hypercalcemia. Signs or symptoms of hypercalcemia may include the following:

  • Nausea or vomiting
  • Loss of appetite
  • Constipation
  • Increased thirst 
  • Frequent urination
  • Muscle weakness 
  • Muscle spasms
  • Feeling tired or fatigued
  • Confusion
  • Bone or joint pain 
  • Bone fractures or easily broken bones

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