Calcium Ionized Serum Test
The Calcium Ionized Serum Test measures the amount of Ionized Calcium, also known as free calcium, in the blood.
Ionized calcium test, or calcium ionized serum test, is occasionally useful when hypercalcemia coexists with an abnormal protein state like myeloma. When calcium is low, this blood test can be helpful in assessing active calcium fraction in hypoproteinemia and acidosis. Calcium in serum exists ionized, bound to organic anions such as phosphate and citrate, and bound to proteins, mainly albumin. Of these, ionized calcium is the physiologically important form. By measuring the serum ionized calcium, insight into the effect of total protein and albumin on serum calcium levels can be obtained. A patient can have high total calcium, with normal ionized calcium and increased total protein and/or albumin, as in dehydration or in myeloma. Women have a greater circadian variation of ionized calcium and intact PTH than men. There is typically an inverse relationship between ionized calcium and phosphate concentration.
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