Quick Facts
- Sample: Blood
- Fasting: Fasting for 8-12 hours is required. Stop biotin consumption at least 72 hours prior to collection.
- Turnaround: 1-4 days. May take longer based on weather, holiday, or lab delays.
What This Test Measures
This test measures Sex Hormone Binding Globulin (SHBG), a protein produced by the liver that binds to sex hormones such as testosterone, dihydrotestosterone (DHT), and estradiol. SHBG is a hormone-binding protein, not a hormone itself, and this test does not directly measure testosterone or estrogen levels. Instead, it reflects how much of these hormones may be carried in a metabolically inactive, bound form in the bloodstream.
Because SHBG levels are influenced by sex, age, and testosterone or estrogen production, this measurement is typically used to help evaluate for a possible testosterone excess or deficiency. SHBG is a directly measured serum value in this test. Results are generally reviewed alongside other clinical information and are not intended to independently diagnose a hormonal condition.
Notice: Biomarkers tested may vary slightly between labs. Please see the sample report(s) for detailed biomarker information.
Benefits
- Helps evaluate for possible testosterone excess or deficiency
- Measures a key protein involved in sex hormone transport
- May help identify factors contributing to infertility
- May help explore causes of low sex drive or erectile dysfunction
- Simple blood test with defined preparation steps
- Results can support discussion with a healthcare provider
Who Is This Test For?
- Individuals experiencing loss of sex drive
- Individuals experiencing erectile dysfunction
- Individuals exploring possible causes of infertility
- Individuals with enlarged breasts or reduced body or facial hair
- Individuals with unexplained brittle bones or anemia
- Individuals experiencing unexplained muscle weakness
How It Works
- Order Your Test Online
- Visit a Local Lab
- Get Results Online
FAQ
1. What is the purpose of this hormone test?
This test measures Sex Hormone Binding Globulin (SHBG), a liver-produced protein that binds to testosterone, DHT, and estradiol. It is a hormone-binding protein test, not a direct measurement of testosterone or estrogen. Results may help a healthcare provider evaluate for a possible testosterone excess or deficiency, alongside other clinical information.
2. Who would benefit from this test?
This test may be considered by individuals with a loss of sex drive, erectile dysfunction, infertility, enlarged breasts, reduced body or facial hair, unexplained brittle bones or anemia, or unexplained muscle weakness. It may also be useful for those exploring possible causes of these symptoms with a healthcare provider.
3. When should I order this test?
You may consider ordering this test if you are experiencing symptoms potentially associated with a testosterone excess or deficiency, or if you and your healthcare provider are exploring possible causes of infertility, decreased sex drive, or erectile dysfunction. This test does not replace a full medical evaluation.
4. How does this test differ from other hormone tests?
This test measures SHBG, a hormone-binding protein, rather than measuring testosterone or estrogen directly. Because SHBG binds to and transports sex hormones in the blood, it provides different information than a direct testosterone or estradiol test. SHBG results reflect hormone-binding capacity, not hormone production itself.
5. Do I need to fast before this test?
Yes. Fasting for 8-12 hours is required. You should also stop biotin consumption at least 72 hours prior to collection.
6. How quickly will I get results?
Results are typically available in 1-4 days. This may take longer based on weather, holiday, or lab delays.
7. How do I interpret the results?
SHBG results are influenced by factors such as sex, age, liver function, thyroid status, and testosterone or estrogen production. Because SHBG is a binding protein, results are generally interpreted alongside other hormone measurements and clinical history rather than on their own. An abnormal SHBG result does not automatically confirm a hormonal condition, and a normal result does not rule one out.
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
8. What should I do if my results are abnormal?
If your SHBG results fall outside the expected range, review them with a qualified healthcare provider. Additional evaluation or testing may be considered based on your symptoms and medical history. This result alone does not provide a complete clinical picture.
9. How often should I get tested?
Testing frequency should be determined as directed by your healthcare provider, based on your individual symptoms and health history.
Pre test preparation
Fasting for 8-12 hours is required. Patients should stop biotin consumption at least 72 hours prior to the collection.
