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Sex Hormone Binding Globulin (SHBG) Serum Test

The SHBG Serum Test helps in evaluating the status of a patient's androgens (male hormones).

Sample Report

Test Code: 082016

Also Known As: SHBG; TeBG; Testosterone-binding Globulin

Methodology: Electrochemiluminescence immunoassay (ECLIA)

Preparation: No fasting required. Stop biotin consumption at least 72 hours prior to the collection.

Test Results: 1-2 days. May take longer based on weather, holiday or lab delays.

Sample Report

Test Code: 30740

Also Known As: SHBG; TeBG; Testosterone-binding Globulin

Methodology: Immunoassay (IA)

Preparation: No fasting required. Stop biotin consumption at least 72 hours prior to the collection.

Test Results: 1-2 days. May take longer based on weather, holiday or lab delays.

Description

Sex Hormone Binding Globulin (SHBG), is a protein produced by the liver. It binds tightly to the hormones, dihydrotestosterone (DHT), testosterone and estradiol (an estrogen), transporting them in the blood in a metabolically inactive form. The amount of SHBG in a patient's blood is affected by sex and age, increased or decreased testosterone or estrogen production. It can also be affected by diseases and conditions such as obesity, liver disease, and hyperthyroidism or hypothyroidism. Adult males test SHBG and testosterone levels to help determine the cause of infertility, decreased sex drive and erectile dysfunction, especially when total testosterone results are found inconsistent with clinical signs.

 The SHBG test is typically used to help evaluate whether a person has an excess or deficiency of testosterone.

Increased SHBG levels may be seen in:

  • Liver disease
  • Hyperthyroidism
  • Eating disorders (anorexia nervosa)
  • Corticosteroids or estrogen use (hormone replacement therapy and oral contraceptives)
  • Decreased sex hormone production (hypogonadism)
  • Pregnancy

Decreases in SHBG are seen with:

  • Obesity
  • Polycystic ovary syndrome
  • Hypothyroidism
  • Androgen (steroid) use
  • Cushing disease

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