Soluble Transferrin Receptor Blood Test

What is the purpose of this test?

The Soluble Transferrin Receptor Blood Test is a specialized blood test that helps assess iron status in the body, particularly when traditional iron tests give unclear results. This test measures the amount of soluble transferrin receptor (sTfR) in the blood, a protein that increases when the body's iron levels are low. Unlike ferritin levels, which can be affected by inflammation or chronic illness, sTfR provides a more accurate picture of iron deficiencyeven in the presence of other health conditions. It is especially useful in distinguishing between iron deficiency anemia and anemia caused by chronic disease.

Doctors often use this test when other iron tests (like ferritin or serum iron) are inconclusive. The sTfR test helps identify early iron deficiency before anemia fully develops and is valuable in evaluating patients with symptoms such as fatigue, weakness, or cognitive difficulties. Since it is less affected by infections or inflammation, this test is considered highly reliable in identifying true iron deficiency, making it a powerful tool for guiding treatment decisions.

Who should get this test?

Individuals may benefit from the Soluble Transferrin Receptor Blood Test if they:

• Have symptoms of iron deficiency or anemia
• Have chronic illnesses (such as rheumatoid arthritis or kidney disease) that may affect standard iron tests
• Are pregnant or planning pregnancy
• Follow a vegetarian or vegan diet low in iron
• Experience chronic fatigue or weakness
• Have unexplained cognitive or developmental delays in children
• Need to monitor response to iron therapy
• Have conditions like celiac disease or gastrointestinal disorders affecting nutrient absorption

When should I order the Soluble Transferrin Receptor Blood Test?

Individuals may consider ordering this test if they have symptoms or exposure concerns related to iron deficiency.

Symptoms to consider:

• Chronic fatigue or unexplained muscle weakness
• Pale skin or shortness of breath
• Dizziness or headaches
• Cold hands and feet
• Rapid heartbeat or chest pain
• Difficulty concentrating or cognitive changes
• Brittle nails or hair loss

If you have these symptoms or suspect an iron imbalance, the Soluble Transferrin Receptor Blood Test can provide useful information to guide you and your doctor in managing your iron levels and overall health.