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Thyroglobulin Antibody and Thyroglobulin Blood Test, IMA or RIA

The Thyroglobulin test is primarily used as a tumor marker to evaluate the effectiveness of treatment for thyroid cancer and to monitor for recurrence.

Sample Report

Test Code: 042060

CPT Code: 86800

Also Known As: Tg;TgAB

Methodology: Immunometric assay (IMA and radioimmunoassay (RIA); Anti-Tg: Beckman Coulter immunometric assay; Tg IMA: Beckman Coulter immunometric assay; Tg RIA: Lab-developed radioimmunoassay LabCorp uses a dual Tg test strategy in an effort to minimize the potential effect of TgAb interference on Tg analysis. All specimens are initially assayed for TgAb by the highly sensitive Beckman Coulter IMA. Samples with TgAb below the detectable limit are assayed for Tg by a sensitive second-generation IMA (Beckman Coulter) with a relatively rapid turnaround time. Specimens with any measurable levels of TgAb are assayed by an RIA method performed at Endocrine Sciences, Calabasas Hills, Calif. This RIA is resistant to interference by TgAb but has a longer turnaround time of five to seven days.

Specimen Type: Blood

Preparation: No fasting required. Stop biotin consumption at least 72 hours prior to the collection.

Test Results: 5-7 days. May take longer based on weather, holiday or lab delays.


Thyroglobulin measurement is intended to aid in monitoring for the presence of orthotropic and/or metastatic thyroid tissues in patients who have had thyroid gland ablation using thyroid surgery with or without radioactivity. Measurement of thyroglobulin antibody is used to identify patient samples that may be affected by TgAb interference in the measurement of Tg. Quantitative TgAb concentrations can also serve as a surrogate tumor marker for Differentiated Thyroid Cancer recurrence and for monitoring changes in tumor mass in certain patients.  

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