Biomarker: E071-IgE Mouse Epithelium

Overview

E071-IgE Mouse Epithelium measures serum IgE antibodies specific to mouse epithelial allergen extracts. Mouse epithelial material can contain allergens from hair, dander, skin, and associated proteins, including the major mouse allergen Mus m 1. A positive result indicates sensitization to mouse-related allergens, but does not by itself confirm clinical allergy or predict reaction severity. The test is clinically useful when evaluating respiratory or skin symptoms associated with household, occupational, or laboratory mouse exposure.

Clinical Use Cases

Evaluating suspected allergy to mice or mouse-derived epithelial material.
Supporting assessment of occupational allergy in laboratory personnel, animal-care workers, researchers, and other people with regular mouse exposure.
Investigating symptoms such as rhinitis, conjunctivitis, asthma, cough, wheezing, urticaria, or other immediate hypersensitivity symptoms after mouse exposure.
Identifying sensitization when skin testing is unsuitable because of skin disease, medication effects, or concern about provoking a severe reaction.
Complementing the clinical history and, when appropriate, skin-prick testing in the evaluation of laboratory animal allergy.

Specimen Types

Serum obtained from venous blood.
Plasma may be accepted by some assay systems, but specimen requirements are method- and laboratory-specific.

Measurement Methods

Allergen-specific serum IgE immunoassay using mouse epithelial extract.
Fluorescence enzyme immunoassay or other automated solid-phase immunoassays.
Enzyme-linked immunosorbent assay in clinical research settings.
Component-resolved assays targeting individual mouse allergens such as recombinant Mus m 1, primarily for research or specialized assessment rather than routine E071 testing.

Test Preparation and Influencing Factors

Fasting is generally not required for an allergy blood test.
No special preparation is usually needed, but the ordering clinician should be told about all medications and supplements.
Do not stop antihistamines or other prescribed medicines unless instructed by a healthcare professional.
Results should be interpreted with the exposure history, symptoms, physical examination, and, when appropriate, skin-test findings.
A positive result indicates sensitization and does not establish that exposure causes symptoms.
The measured IgE concentration does not reliably predict the severity of a future allergic reaction.
Extract composition can vary, and epithelial extracts may contain multiple mouse allergen proteins, so results may not identify the specific protein responsible for sensitization.
Smoking, parasitic infection, and other conditions can affect broader IgE testing, although these factors do not specifically establish mouse allergy.