Quick Facts
- Sample: Blood and urine
- Fasting: 12 hours required
- Turn-around: 1–2 business days. May take longer based on weather, holiday, or lab delays.
Benefits
- Comprehensive screening - Tests 40+ biomarkers across 6 tests to identify common fatigue causes
- Fast results - Get answers in 1-2 days without waiting weeks for appointments
- No prescription needed - Order directly online and visit any partnering lab nationwide
- Complete evaluation - Screens for anemia, thyroid issues, diabetes, infections, and more
- Confidential results - Access your results securely online with full privacy protection
Who Is This Test For?
- People experiencing persistent tiredness lasting more than a few weeks
- Individuals with unexplained exhaustion not improved by rest or sleep
- Those with family history of anemia, thyroid disease, or diabetes
- Anyone wanting proactive health screening for common fatigue-related conditions
- People experiencing fatigue with additional symptoms like weight changes or cognitive issues
How It Works – Just 3 Steps
- Order online - Purchase your test and receive lab order instantly
- Visit a lab - Get blood drawn and provide urine sample at any partnered location
- Get results - Access comprehensive results online within 1-2 business days
FAQ
What conditions does this test screen for? This panel screens for anemia, thyroid dysfunction, diabetes, kidney disease, liver problems, metabolic disorders, and systemic inflammation that commonly cause fatigue.
Do I need to fast before the test? Yes, you must fast for 12 hours before your blood draw. You should also stop taking biotin supplements 72 hours prior to testing.
How accurate is this test for identifying fatigue causes? Comprehensive fatigue panels have 80-90% diagnostic sensitivity for identifying treatable causes of persistent tiredness (Mayo Clinic 2023).
Can I take my regular medications before the test? Continue most prescribed medications unless specifically instructed otherwise. Consult your healthcare provider if you're unsure about any medications.
What if my results are abnormal? Abnormal results require follow-up with a healthcare provider for proper diagnosis and treatment planning.
How often should I repeat this test? For monitoring chronic conditions, testing is typically recommended every 3-12 months. For initial screening, repeat testing depends on your results and symptoms.
More Details
What is the purpose of this test?
This comprehensive panel identifies potential medical causes of unexplained, persistent fatigue by evaluating a broad range of blood and urine biomarkers. It screens for disorders such as anemia, thyroid dysfunction, metabolic imbalances, infections, kidney issues, and liver problems that commonly contribute to chronic tiredness (Mayo Clinic 2023).
Who would benefit from this test?
Anyone experiencing chronic tiredness or exhaustion without an obvious source would benefit from this screening. It's particularly valuable for individuals with a family or personal history of conditions like anemia, thyroid disease, or diabetes. People experiencing fatigue lasting more than a few weeks, unrelieved by sleep, or associated with other symptoms should consider this comprehensive evaluation (CDC 2024).
When should I order the Fatigue Blood and Urine Test Panel?
Order this test if fatigue persists for more than a few weeks, remains unrelieved by adequate sleep, or occurs alongside other symptoms such as weight loss, fever, or cognitive changes. It's also recommended when routine wellness labs haven't identified the cause of your tiredness, or if you want proactive screening for fatigue-related conditions (Johns Hopkins Medicine 2023).
How do I interpret the results?
Each biomarker is compared against established reference ranges, with abnormal findings flagged for review. Results are best interpreted with a healthcare provider for appropriate diagnosis and treatment planning.
Low Hemoglobin
- May indicate: Anemia (iron deficiency common)
- Next steps: Iron studies, dietary changes, supplements
Elevated TSH
- May indicate: Hypothyroidism (underactive thyroid)
- Next steps: Thyroid hormone replacement therapy
High Glucose
- May indicate: Diabetes or prediabetes
- Next steps: Lifestyle changes, medication if needed
Abnormal Kidney Function
- May indicate: Kidney disease or dysfunction
- Next steps: Nephrology referral, further testing
Elevated Liver Enzymes
- May indicate: Liver inflammation or disease
- Next steps: Lifestyle changes, additional liver testing
Early detection through comprehensive screening can improve treatment outcomes and reduce healthcare costs by up to 30% (Johns Hopkins 2023).
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
Pre-test preparation
Fast for 12 hours before your blood draw, consuming only water during this period. Discontinue biotin supplements at least 72 hours prior to testing, as they can interfere with certain lab results. Continue most prescribed medications unless your healthcare provider instructs otherwise. Avoid strenuous exercise 24 hours before testing for most accurate results.
How often should I get tested?
- Initial fatigue screening: As needed based on symptoms
- Monitoring thyroid treatment: Every 6–12 months
- Chronic disease management: Every 3–6 months
- General wellness screening: Annually for adults over 40
- High-risk individuals: Every 6 months
Why early detection matters
Fatigue affects up to 20% of U.S. adults at any given time, with many cases having treatable underlying causes (CDC 2024). Anemia, present in 5-12% of Americans, is a common and correctable cause of persistent tiredness. Thyroid disorders affect nearly 5% of the population and can significantly impact energy levels when untreated (American Thyroid Association 2023). Early identification allows for prompt treatment and symptom relief.
Related tests you may consider
Vitamin B12 and Folate Panel - Identifies deficiencies commonly linked to fatigue, especially important for older adults or those with digestive disorders.
Hormone #1 Baseline Panel for Women - Assesses adrenal hormones and female reproductive hormones for deeper evaluation of endocrine-related fatigue.
Hormone #1 Baseline Panel for Men - Assesses adrenal hormones and male reproductive hormones for deeper evaluation of endocrine-related fatigue.
