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Myeloperoxidase Antibody (MPO) Blood Test

The MPO Blood Test measures the antibody levels of Myeloperoxidase. Elevated Myeloperoxidase antibodies are associated with vascular diseases, lupus, and other inflammatory conditions.

Sample Report

Test Code: 8796

Also Known As: Anti-Myeloperoxidase; Crescentic Glomeruloephritis; Churg-Strauss Syndrome

Methodology: Immunoassay (IA)

Preparation: Fasting for 12 hours required.

Test Results: 5-7 days. May take longer based on weather, holiday or lab delays.


Myeloperoxidase (MPO) is an enzyme released by white blood cells that fight microbial infections. Its levels increase during inflammation. MPO destroys pathogens by creating a chemical compound called hypochlorous acid. Hypochlorous acid is not only produced in the body to kill pathogens, but the same chemical is used routinely in daily life as a disinfectant. For example, hypochlorous acid is an important component of bleach disinfectant. During infection and inflammation, MPO levels are elevated. This is because white blood cells produce MPO in abundance to fight pathogens. The Myeloperoxidase Blood Test helps determine the levels of MPO in blood. It is used to evaluate infection and inflammation.

Following are the clinical indications for performing the Myeloperoxidase Blood Test: 

  • Following up to, and in conjunction with, an electrocardiogram (EKG or ECG) and/or cardiac biomarkers tests
  • Chest pain
  • Fever
  • Abnormal heart rate
  • Fatigue and headache
  • Redness

Approximately 90% of patients with a P-ANCA pattern by IFA have myeloperoxidase-specific antibodies.

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