Quick Facts
- Sample: Blood
- Fasting: No special preparation is required
- Turnaround: 5-7 days. May take longer based on weather, holiday, or lab delays. At this time, the lab is experiencing delays, which could add 7 business days to the normal turnaround time for results.
What This Test Measures
This test measures estradiol (E2), sensitive, a circulating steroid hormone, using LC/MS-MS methodology. LC/MS-MS methodology allows for more precise detection at the lower end of the estradiol range than a standard immunoassay test, making it suited to evaluating low estradiol levels.
This is a directly measured hormone level, not a calculated value, and the result reflects total circulating estradiol rather than a free hormone fraction. The test does not measure a stimulating hormone, hormone-binding protein, precursor, or metabolite. It measures estradiol alone and does not include any other reproductive hormone.
Benefits
- Detects low estradiol levels with greater sensitivity than standard immunoassay tests
- Uses LC/MS-MS methodology for improved accuracy at low concentrations
- Helps a healthcare provider evaluate estradiol status related to infertility concerns
- Appropriate for the lower estradiol ranges typically seen in men and postmenopausal women
- Provides estradiol results that can be reviewed alongside other clinical findings
Who Is This Test For?
- Women whose healthcare provider suspects low estradiol as a factor in infertility
- Men who want to understand their circulating estradiol levels
- Men with symptoms that may relate to elevated estradiol, such as gynecomastia
- Postmenopausal women whose estradiol levels may be low due to reduced ovarian production
- Individuals whose provider wants a sensitive estradiol measurement at the lower range
How It Works
- Order Your Test Online
- Visit a Local Lab
- Get Results Online
FAQ
1. What is the purpose of this hormone test?
This test directly measures sensitive estradiol (E2) using LC/MS-MS methodology. It is designed to provide a more precise reading at the lower end of the estradiol range and may help a healthcare provider evaluate estradiol status when low levels are a concern. It does not measure any other hormone.
2. Who may benefit from this test, and when should it be ordered?
This test may be useful for women whose healthcare provider is evaluating whether low estradiol may be contributing to infertility. It may also be appropriate for men reviewing elevated estradiol levels associated with gynecomastia and postmenopausal women whose provider wants a sensitive measurement within the lower range resulting from decreased ovarian production. It does not replace a full medical evaluation.
3. How does this test differ from other hormone tests?
Unlike standard immunoassay-based estradiol testing, LC/MS-MS methodology allows for more precise detection at low estradiol concentrations. This test measures circulating estradiol directly; it does not measure free estradiol, a stimulating hormone, a hormone-binding protein, or any other related hormone.
4. Do I need to prepare for this test?
No special preparation is required.
5. How quickly will I receive my results?
Results are typically available within 5–7 days, although weather, holidays, or laboratory delays may extend this timeframe. The laboratory is currently experiencing delays that could add seven business days to the normal turnaround time.
6. How do I interpret the results?
Estradiol results should be interpreted in the context of your sex, age, menstrual cycle stage, menopausal status, and any hormone supplementation. Because estradiol is a single measurement, the result is often reviewed alongside other clinical information and, when relevant, other hormone levels. A single result does not confirm or rule out a hormonal condition on its own. Your healthcare provider can interpret it within your overall health picture.
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
7. What should I do if my results are abnormal?
Review an estradiol result that falls outside the expected range with a qualified healthcare provider. Based on your health history and other findings, they can determine whether additional evaluation is appropriate.
8. How often should I get tested?
Your healthcare provider should determine the appropriate testing frequency based on your individual health needs and reason for testing.
Pre test preparation
No special preparation is required.
