Quick Facts
- Sample: Blood
- Fasting: No special preparation is required
- Turnaround: 5-7 days. May take longer based on weather, holiday, or lab delays. At this time, the lab is experiencing delays, which could add 7 business days to the normal turnaround time for results.
What This Test Measures
This test measures estradiol (E2), sensitive, a circulating steroid hormone, using LC/MS-MS methodology. LC/MS-MS methodology allows for more precise detection at the lower end of the estradiol range than a standard immunoassay test, making it suited to evaluating low estradiol levels.
This is a directly measured hormone level, not a calculated value, and the result reflects total circulating estradiol rather than a free hormone fraction. The test does not measure a stimulating hormone, hormone-binding protein, precursor, or metabolite. It measures estradiol alone and does not include any other reproductive hormone.
Benefits
- Detects low estradiol levels with greater sensitivity than standard immunoassay tests
- Uses LC/MS-MS methodology for improved accuracy at low concentrations
- Helps a healthcare provider evaluate estradiol status related to infertility concerns
- Appropriate for the lower estradiol ranges typically seen in men and postmenopausal women
- Provides estradiol results that can be reviewed alongside other clinical findings
Who Is This Test For?
- Women whose healthcare provider suspects low estradiol as a factor in infertility
- Men who want to understand their circulating estradiol levels
- Men with symptoms that may relate to elevated estradiol, such as gynecomastia
- Postmenopausal women whose estradiol levels may be low due to reduced ovarian production
- Individuals whose provider wants a sensitive estradiol measurement at the lower range
How It Works
- Order Your Test Online
- Visit a Local Lab
- Get Results Online
FAQ
1. What is the purpose of this hormone test?
This test measures estradiol (E2), sensitive, using LC/MS-MS methodology. It is designed to provide a more precise reading at the lower end of the estradiol range than standard immunoassay testing. The result may help a healthcare provider evaluate estradiol status, particularly in situations where low levels are a concern. This test measures estradiol directly and does not evaluate any other hormone.
2. Who would benefit from this test?
This test may be useful for women whose healthcare provider suspects low estradiol may be contributing to infertility, since accurate measurement at the lower range can be relevant to that evaluation. It may also be useful for men, including those interested in understanding elevated estradiol levels associated with gynecomastia, and for postmenopausal women, whose estradiol levels are generally lower due to decreased ovarian production.
3. When should I order this test?
You may consider this test if a healthcare provider is evaluating potential causes of infertility related to low estradiol. It may also be considered by men interested in reviewing their estradiol levels, or by postmenopausal women whose provider wants a sensitive measurement at the lower range. This test does not replace a full medical evaluation.
4. How does this test differ from other hormone tests?
This test measures estradiol directly, as a circulating hormone, using LC/MS-MS methodology rather than standard immunoassay methodology. LC/MS-MS methodology allows for more precise detection at low estradiol concentrations, which distinguishes this test from standard immunoassay-based estradiol testing. This test does not measure free estradiol, a stimulating hormone, a hormone-binding protein, or any other related hormone.
5. Do I need to fast before this test?
No special preparation is required for this test.
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
6. How quickly will I get results?
Results are typically available in 5-7 days, though this may take longer based on weather, holiday, or lab delays. At this time, the lab is experiencing delays, which could add 7 business days to the normal turnaround time for results.
7. How do I interpret the results?
Estradiol results are interpreted in the context of factors such as sex, age, menstrual cycle stage, menopausal status, and any hormone supplementation. Because estradiol is one measurement, results are often reviewed alongside other clinical information and, when relevant, other hormone levels. A single result does not confirm or rule out a hormonal condition on its own. Your healthcare provider is best positioned to interpret your result within your overall health picture.
8. What should I do if my results are abnormal?
If your estradiol result falls outside the expected range, review the result with a qualified healthcare provider. They can help determine whether additional evaluation is appropriate based on your health history and other findings. This test result alone does not provide a complete clinical picture.
9. How often should I get tested?
Testing frequency should be determined as directed by your healthcare provider, based on your individual health needs and reason for testing.
Pre test preparation
No special preparation is required.
