LabCorp Test

Alpha-1 Antitrypsin Blood Test

Quick Overview

The alpha-1 antitrypsin test helps to diagnose the cause of early onset emphysema and/or liver dysfunction.

Test #001982


Availability: In stock

Also Known As AAT; Acute Phase Proteins; Alpha1-Antitrypsin Serum; Alpha1-Protease Inhibitor; A1AT; Alpha-1 Antitrypsin Deficiency Testing; AAT testing
Preparation Fasting for 10-12 hours required.
Test Results 1-2 days. May take longer based on weather, holiday or lab delays.

An alpha-1 antitrypsin test (AAT) may be ordered when a person under 40 years of age develops a chronic cough or bronchitis, wheezing, or short of breath after exertion and/or shows other signs of emphysema. This is especially true when the patient has not been exposed to known lung irritants, is not a smoker, and when the lung damage appears to be located low in the lungs. AAT testing may also be done if you have a close relative with alpha-1 antitrypsin deficiency.

The American Thoracic Society recommends AAT testing when individuals are diagnosed with certain conditions such as: 

  • Emphysema at a young age (younger than 45 years old) and/or no obvious risk factors for the disease, such as smoking
  • Bronchiectasis, a condition in which the airways are stretched and/or widened
  • Asthma that is difficult to treat
  • Liver disease with no known cause
  • A skin disease called panniculitis, an uncommon complication of AAT deficiency that is characterized by red, tender nodules on the skin

 Alpha-1 antitrypsin deficiency has been associated with a number of diseases:  

  • Cirrhosis
  • COPD
  • Pneumothorax
  • Asthma
  • Wegener's granulomatosis
  • Pancreatitis
  • Gallstones
  • Bronchiectasis
  • Pelvic organ prolapse
  • Primary sclerosing cholangitis
  • Autoimmune hepatitis
  • Emphysema, predominantly involving the lower lobes and causing bullae
  • Secondary Membranoproliferative Glomerulonephritis
  • Cancer
    • Hepatocellular carcinoma (liver)
    • Bladder carcinoma
    • Gallbladder cancer
    • Lymphoma
    • Lung cancer

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